Palladium-Catalyzed Direct Arylation of 2-Pyridylmethyl Silanes with Aryl Bromides

Tingzhi Lin,¹Pengcheng Qian,¹Yan-En Wang,²Mingjie Ou,¹Long Jiang,³Chen Zhu,¹YuchuanXu,¹Dan Xiong,¹and Jianyou Mao,*^,1

¹Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engi-neering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211800, P. R. China.

²College of Science, Hebei Agricultural University, Baoding 071000, P. R. China.

³Institute of Advanced Synthesis (IAS), Northwestern Polytechnical University (NPU), Xi'an, 710072, China. Yangtze River Delta Research Instituteof NPU, Taicang Jiangsu, 215400, P. R. China.

Abstract:The firstpalladium-catalyzeddirectarylation of2-pyridylmethylsilaneswith aryl bromides to generate a diverse array ofaryl(pyridyl)-methylsilane derivativeshas been developed. This protocol facilitates access tovarious kinds ofheterocycle-containingsilanes in good to excellent yields (40examples,66−97% yield) withgoodfunctional group tolerance.The scalability of this transformation is demonstrated.

DOI:10.1021/acs.orglett.1c00677(2020年影响因子:6.091).

论文链接：https://pubs.acs.org/doi/10.1021/acs.orglett.1c00677