Practical allylation with unactivated allylic alcohols under mild conditions

Shuangshuang Li^a, Ju Qiu^a,Bowen Li^a,Zuolian Sun^a, Peizhong Xie^a*, and Teck-Peng Loh^ab*

^aSchool of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.

bDivision of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.

Abstract:A practical palladium/calcium catalytic system was developed for dehydrative allylation concerning unactivated allylic alcohols. EtOH solvent with H₂O additive was identified as powerful media to accelerate proton transfer. That catalytic system and environmentallybenignmedia enabled a variety ofsoftcarbonicnucleophiles and allylic alcohols reacted smoothly at room temperaturewithwater as the only byproduct. A wide-spectrum of allylic compounds bearinga variety offunctional groups can be obtained with high to excellent yields.

Org. Chem. Front.2021,8, 3354-3359.（影响因子：5.281）

论文链接：https://pubs.rsc.org/en/content/articlepdf/2021/qo/d1qo00490e