Dual Role of (NH₄)₂CO₃Enables Defluorinative Synthesis of

βFluoroalkylated Aminovinyl Ketones

Yu-Lan Chen(陈玉兰),^aWei Han,^aMan-Hang Feng,^aPeng-Yuan Zhang,^aMengtao Ma,^bZhi-Liang Shen,*^,aand Xue-Qiang Chu*^,a

^aTechnical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China.

^bDepartment of Chemistry and Materials Science, College of Science, Nanjing Forestry University, Nanjing 210037, China.

Abstract:A modular multicomponent reaction of readily available fluoroalkyl alkenes, amidines, ammonium carbonate, and water was developed for the facile construction ofβ-fluoroalkylated

aminovinyl ketones, which provided chemists a novel access to value-added organofluorine compounds. The reaction proceeded regio-/stereoselectively under mild conditions and exhibited good functional group tolerance. Cheap, stable, and low-toxic inorganic salt (NH₄)₂CO₃was first found to act as both a nitrogen source and a carbonyl equivalent in the multi-bond-forming process.

Org. Lett.2022,24, 9086−9091(Impact factor: 6.072)

论文链接：https://doi.org/10.1021/acs.orglett.2c03745.