Lecture Time: 10:30 on 13th April, 2016

Lecture Room: C501 of National Sicence Park

Haixia Gong, MD, PhD.
1248 Western Westgate Terrace, Chicago Illinois 60607
312-413-5333 (Office); 847-757-1212 (Cell)
gonghaix@uic.edu;gonghaix@gmail.com

Professional Experience
Assistant Professor 2016.5 -
University of Arizona, College of Medicine, Department of Medicine, Tucson, Arizona
Research Assistant Professor 2010.7 -2016.4
University of Illinois at Chicago, Department of Pharmacology, Chicago, Illinois
Postdoc Associate 2007.3-2010.6
University of Illinois at Chicago, Department of Pharmacology, Chicago, Illinois
Postdoc Fellow 2004.7-2007.2
Northwestern University, Cancer research institute of ENH, Evanston, Illinois
Education
PhD in Pediatrics, Nanjing Medical University, China. 1998.9-2004.7
MD in Pediatrics, Wenzhou Medical College, China. 1993.9-1998.7
Research Support
1. 13SDG16910050 from AHA Gong H (PI) 07/01/13-06/30/17
Galpha13 Switch Signals Disassembly of Adherens Junctions and Increase Endothelial Permeability
This project focuses on characterizing the mechanisms of Galpha13 in disassembly VE-cadherin-based adherence junctions via Src activation.
2. 5 R01 HL45638-27 Malik AB (PI) Gong H (Co-investigator) 04/01/14-3/31/19
Regulation of Endothelial Junction Stabilization and Lung Edemagenesis in Sepsis
The focus of this work is on the lung endothelium, in which the studies will establish the relevance of hypoxia inducible factors, HIF1α and HIF2α and the upstream prolyl hydroxylases, in the pathophysiology of ALI/ARDS. We will define whether activation of HIF through inhibition of PHDs, potentially druggable targets, are a fundamental adaptive mechanism that restore endothelial barrier function and prevent lung edema in the context of lung inflammation and ALI/ARDS.
3. 5 P01 HL 060678-15 Malik AB (PI) Gong H (Co-investigator) 03/01/16-02/28/21
Project 1: Transcellular Mechanisms of Endothelial Permeability and Pulmonary Edema
This project focuses on characterizing the mechanisms involved in the movement of solutes and fluids
through endothelial cells by transcytosis.
4. 1R01HL128359-01. Tiruppathi C (PI) Gong H (Co-investigator) 07/01/15-06/30/19
Endothelial Cell Deubiquitinase A20 Signals Repair of Lung Vascular Injury
The major goals of this project are to study the role of endothelial cell-expressed ubiquitin editing
enzyme A20 in regulating the expression of VE-cadherin and VE-PTP at endothelial cell-cell junction
and thereby restoring endothelial barrier integrity.
5. 5 R01 HL090152-09 Malik (PI) Gong H (Co-investigator) 07/01/16-06/30/21
iPSC-derived Endothelial Progenitor Cell Treatment of Lung Vascular Injury
The major goal of the project is to test the feasibility of using iPSC-derived endothelial progenitor cells
(EPCs) alone or in combination with hematopoietic stem cells (HSCs) to restore lung endothelial barrier
function and regeneration of lung vessels after lung injury induced by sepsis.
Honros and Awards
1. Dr. Isadore and Elva Pitesky Pharmacology Research Award (2015).
2. Honorable Mention Certificate winner at UIC College of Medicine Research Forum (2010).
3. Bristow Postdoctoral Fellow Poster Award at UIC Department of Pharmacology retreat (2009).
Invited Lecture
2010 ASH annual meeting: G13 and talin cordinate integrin inside-out and outside-in signaling by “time-sharing” 3 cytoplasmic domain. Orlando, Florida
Selected Publications
1. Gong H, Sassmann A, Liu M, Chai M, Mastej V, Mittal M, Offermanns S, and Malik AB. Protease-activated receptor 1 (PAR1) scaffolding of TGFRII regulates endothelial differentiation and neovascularization. Stem Cell Reports (under revision).
2. Gong H, Liu M, Mastej V, Chai M, Merrill, BJ, Malik AB. CRISPR/Cas9 mediated gene deletion in primary human endothelial cells (in preparation).
3. Gong H, Rehman J, Tang H, et al. HIF2α-Signaling inhibits adherens junctional disruption in acute lung injury. J Clin Invest. 2015; 125(2): 652-664.
4. Gong H, Gao X, Feng S, et al. Evidence of a common mechanism of disassembly of adherens junctions through Gα13 targeting of VE-cadherin. J Exp Med. 2014; 211(3): 579-91.
5. Gong H, Shen B, Flevaris P, et al. G protein subunit Gα13 binds to integrin α2bβ3 and mediates integrin “outside-in” signaling. Science. 2010; 327 (5963): 340-3.
6. Flevaris P, Stojanovic A, Gong H, et al. A molecular switch that controls cell spreading and retraction. J Cell Bio. 2007; 179 (3): 553-65.
7. Guo X, *Gong H, Gao Y, et al. A mutation in the signal peptide of rat resistin gene inhibits 3T3-L1 preadipocytes differentiation. Acta Pharmacol Sin. 2004; 25 (12): 1705-11. (*: Co-first author).
8. Gong H, Ni Y, Guo X, et al. Resistin promotes 3T3-L1 preadipocyte differentiation. Eur J Endocrinol, 2004; 50(6): 885-92.
9. Gong H, Guo X, Fei L, et al. Apoptosis and lipolysis of adipocytes induced by neuropeptide Y-Y5 receptor antisense oligodeoxynucleotides in obese rats. Acta Pharmacol Sin. 2003; 24(6): 569-75.