报告时间：2016年5月20日上午9:30
报告地点：科技创新大楼C501室
报告题目：RECENT ADVANCES IN CATALOMICS

报告人介绍：
姚少钦教授，1993年在美国俄亥俄州立大学获得学士学位，1998年在美国普渡大学获得博士学位，毕业后分别与加利福尼亚大学伯克利分校癌症研究院，和斯克里普斯研究所从事博士后研究工作。2001年加盟新加坡国立大学化学系，2011年起获聘国立大学终身正教授，2012年起被聘为首席教授。他在担任著名期刊《德国应用化学》国际咨询委员会成员的同时，并担任很多国际刊物的评审。研究兴趣包括化学蛋白质组学、小分子探针荧光探针、高通量筛选等，利用化学、生物、材料等多学科交叉领域，开拓崭新的研究方法去探索生命科学中具有现实意义的课题。迄今为止已经在《自然》，《美国科学院院报》，《自然通讯》，《美国化学会会刊》，《德国应用化学》等杂志上发表SCI论文170多篇。

RECENT ADVANCES IN CATALOMICS

SHAO Q YAO
Department of Chemistry, National University of Singapore, Singapore 117543

ABSTRACT

Enzymes catalyze virtually every cellular process and metabolic exchange. They not only are instrumental in sustaining life but also are required for its regulation and diversification. Diseases such as cancer can be caused by minor changes in enzyme activities. In addition, the unique enzymes of pathogenic organisms are ripe targets for combating infections. Consequently, nearly one-third of all current drug targets are enzymes. Little, however, is understood about the physiological roles, substrate specificity, and downstream targets of the vast majority of these important proteins. A key step toward the biological characterization of enzymes, as well as their adoption as drug targets, is the development of global solutions that bridge the gap in understanding these proteins and their interactions. Catalomics is an emerging field in chemical biology in which chemical and biological tools are developed, enabling large-scale studies of enzymes at the organism level.¹In this presentation, I will discuss latest progress made in my laboratory in relation to drug discovery. Specifically, I will discuss our recent results on using microarray-based technologies for discovery of potential drug candidates.²In addition, I will describe our recent strategy on the development of small molecule chemical probes for cell-based proteome profiling of potential drug targets (on and off), and imaging applications.^3,4Finally, I will discuss our recent efforts in the development of novel drug delivery methods by using mesoporous silica nanoparticles (MSNs) capped with oligonucleotides to achieve endocytosis-independent cellular uptake and intracellular controlled release of drugs with novel theranostic properties.⁵

References

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4. a) Qian, L.; Li, L.; Yao, S.Q., Acc. Chem. Res. 2016, 49, 626-634; b) Li, L.; Zhang, C.-W.; Ge, J.; Qian, L.; Chai, B-H.; Zhu, Q.; Lee, J.-S.; Lim, K.-L.; Yao, S.Q., Angew. Chem. Int. Ed. 2015, 54, 10821-10825; c) Li. L.; Zhang, C.-W.; Chen, G.Y.J.; Zhu, B.; Chai, C.; Xu, Q.-H., Tan, E.-K.; Zhu, Q.; Lim, K.-L.; Yao, S.Q., Nat. Commun. 2014, 5, 3276.
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