报告题目：Recent Progress on Activatable Photosensitizers and Fluorescent Probes

报告人：Juyoung Yoon教授

邀请人：李林 教授

报告时间：12月8日（星期二）9:00

报告地点：科技创新大楼C501

摘要

Switchable phototheranostic nanomaterials are of particular interest for specific biosensing, high-quality imaging, and targeted therapy in the field of precision nanomedicine. Here, we develop a “one-for-all” nanomaterial (NanoPcTBs) that self-assembles from flexible and versatile phthalocyanine building blocks. Fluorescence and reactive oxygen species (ROS) generation could be triggered depending on a targeted, protein-induced, partial disassembly mechanism, which creates opportunities for low-background fluorescence imaging and activatable photodynamic therapy (PDT). We also reported a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which have the capability of undergoing nucleic acid-responsive disassembly. On the other hand, thein vivospecific binding between albumin and PcS, arising from the disassembly of injected NanoPcS, was recently confirmed using an inducible transgenic mouse system. In a recent investigation, we devised a novel molecular design approach to create heavy-atom-free photosensitizers for enhanced photodynamic therapy under hypoxia conditions. The thionaphthalimides display dramatically enhanced quantum yields for photosensitized singlet oxygen formation (Φ_∆~ 1.00, in air-saturated acetonitrile).Finally, recent progress from our group on the fluorescent probes based onN-heterocyclic carbene (NHC) boranes for HOCl will be also presented.

个人简介

Prof. Juyoung Yoon，韩国梨花女子大学化学与纳米科学院杰出教授，韩国科学院院士。在荧光探针、分子识别、生化传感器以及新型有机功能材料等研究方向取得了卓越的成就，在韩国和国际上享有较高知名度和影响力。目前已在Chem. Rev., Chem. Soc. Rev., Chem, J. Am. Chem. Soc., Angew. Chem. Int. Ed.等杂志发表学术论文380余篇，H-index 103，他引超过41000次。自2014年至今，连续7年被评为全球高被引科学家（highly cited researcher）。