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关于韩国梨花女子大学Juyoung Yoon教授学术报告的通知
添加时间:2020/12/02 发布:
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报告题目:Recent Progress on Activatable Photosensitizers and Fluorescent Probes

报告人:Juyoung Yoon教授

邀请人:李林 教授

报告时间:12月8日(星期二)9:00

报告地点:科技创新大楼C501

摘要

Switchable phototheranostic nanomaterials are of particular interest for specific biosensing, high-quality imaging, and targeted therapy in the field of precision nanomedicine. Here, we develop a “one-for-all” nanomaterial (NanoPcTBs) that self-assembles from flexible and versatile phthalocyanine building blocks. Fluorescence and reactive oxygen species (ROS) generation could be triggered depending on a targeted, protein-induced, partial disassembly mechanism, which creates opportunities for low-background fluorescence imaging and activatable photodynamic therapy (PDT). We also reported a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which have the capability of undergoing nucleic acid-responsive disassembly. On the other hand, thein vivospecific binding between albumin and PcS, arising from the disassembly of injected NanoPcS, was recently confirmed using an inducible transgenic mouse system. In a recent investigation, we devised a novel molecular design approach to create heavy-atom-free photosensitizers for enhanced photodynamic therapy under hypoxia conditions. The thionaphthalimides display dramatically enhanced quantum yields for photosensitized singlet oxygen formation (Φ~ 1.00, in air-saturated acetonitrile).Finally, recent progress from our group on the fluorescent probes based onN-heterocyclic carbene (NHC) boranes for HOCl will be also presented.


个人简介

Prof. Juyoung Yoon,韩国梨花女子大学化学与纳米科学院杰出教授,韩国科学院院士。在荧光探针、分子识别、生化传感器以及新型有机功能材料等研究方向取得了卓越的成就,在韩国和国际上享有较高知名度和影响力。目前已在Chem. Rev., Chem. Soc. Rev., Chem, J. Am. Chem. Soc., Angew. Chem. Int. Ed.等杂志发表学术论文380余篇,H-index 103,他引超过41000次。自2014年至今,连续7年被评为全球高被引科学家(highly cited researcher)。

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