李学明，教授，博士生导师，药学院院长。

个人简介：

中国药学会药剂专委会委员、江苏省药学会药剂专委会副主任委员、江苏省药学会促进医药产业发展专委会委员等，兼任国家药品监督管理局药物制剂及辅料研究与评价重点实验室学术委员会委员，兼任国家药监局药品审评专家、江苏省药监局药品审评专家、国家高新技术企业审评专家等。被评为江苏省“青蓝工程”优秀青年骨干教师，南京市有突出贡献中青年专家，获中国产学研合作创新奖。

多年来一直从事药剂学、药物动力学、药用高分子材料学等方面的教学科研工作，主持或承担了国家“重大新药创制”、国家自然科学基金、江苏省自然科学基金等多项国家和省部级项目，以及多项企业合作课题。发表学术论文100余篇，获得发明专利授权20余项。指导的研究生曾获“挑战杯”全国大学生课外学术科技作品二等奖，指导的本科生曾获江苏省优秀毕业论文一等奖。

2012年及2015年在国家药品审评中心担任外聘专家从事药品技术审评工作。2015年7月-2016年7月在美国密歇根大学药学院做访问学者。

主要研究方向：

递药新技术、缓控释制剂、生物医学新材料等。

近期代表性论文：

1. Shuilin Shen, Zimeng Zhang, Haixiao Huang, Jing Yang, Xinyue Tao, Zhengjie Meng, Hao Ren* andXueming Li*. Copper-induced injectable hydrogel with nitric oxide for enhanced immunotherapy by amplifying immunogenic cell death and regulating cancer associated fbroblasts[J]. Biomaterials Research, 2023, 27:44(IF:15.863/ Q1)

2. Jing Yang, Yunhao Bai, Shuilin Shen, Xinyue Tao, Chengyu Ma, Bowen Fu, Qihao Dai, Jian Wu, Zhengjie Meng, Qingmin Sun*,Xueming Li*, Hao Ren*. An Oral Nano-antioxidant for Targeted Treatment of Inflammatory Bowel Disease by Regulating Macrophage Polarization and Inhibiting Ferroptosis of Intestinal Cells[J]. CHEM ENG J, 2023, 465: 142940(IF:16.744/Q1)

3. Zhengjie Meng, Bowen Fu, Zheng Yang, Yuhua Xu, Haixiao Huang, Yunhao Bai, Xue Fang, Shuilin Shen, Jing Yang, Jiahui Yong, Xinyue Tao, Chenyu Ma, Wenjun Miao, Hao Ren, Yonglu Wang*, Hao Xu*,Xueming Li*. Polydopamine-coated thalidomide nanocrystals promote DSS-inducedmurine colitis recovery through Macrophage M2 polarization together withthe synergistic anti-inflammatory and anti-angiogenic effects. INT J PHARMACEUT, 2023, 630: 122376(IF 6.510/Q1)

4. Zhengjie Meng*, Xue Fang, Bowen Fu, Cheng Qian, Zheng Yang, Yunhao Bai, Xinyue Tao, Haixiao Huang, Chenyu Ma, Wenjun Miao, Hao Ren, Aiyun Wang*,Xueming Li*. Tumor immunotherapy boosted by R837 nanocrystals through combining chemotherapy and mild hyperthermia[J]. J CONTROL RELEASE, 2022, 350: 841–856(IF: 11.467/Q1)

5. Ren Hao*, Yong Jiahui, Yang Qingqing, Yang Zhen, Liu Zhangya, Xu Yan, Wang Hao, Jiang Xing,Li Xueming*. Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy[J]. ACTA PHARM SIN B, 2021，11(10): 3244-3261(IF: 14.903/Q1)

6. Meng Zhengjie*, Wang Hao, Fang Xue, Liu Zhangya, Yang Zhen, Yong Jiahui, Yang Qingqing, Bai Yunhao, Ren Hao, Xu Hao*,Li Xueming*. Surface Decoration via Physical Interaction of Cupric Diethyldithiocarbamate Nanocrystals and Its Impact on Biodistribution and Tumor Targeting. ACS APPL MATER INTER, 2021, 13(31): 36894-36908.(IF: 10.383/Q1)

7. Hao Ren*, Qingqing Yang, Jiahui Yong, Xue Fang, Zheng Yang, Zhangya Liu, Xing Jiang, Wenjun Miao a andXueming Li*.Mitochondria targeted nanoparticles to generate oxygen and responsive-release of carbon monoxide for enhanced photogas therapy of cancer. BIOMATER SCI, 2021, 9: 2709-2720(IF: 7.590/Q1)

8. Yan Xu, Jiwei Liu, Zhangya Liu, Hao Ren,* Jiahui Yong, Weilan Li, Hao Wang, Zheng Yang, Yonglu Wang, Guoguang Chen*, andXueming Li*. Blockade of Platelets Using Tumor-Specific NO-Releasing Nanoparticles Prevents Tumor Metastasis and Reverses Tumor Immunosuppression. ACS Nano, 2020, 14: 9780-9795(IF: 18.027/Q1)

9. Jiwei Liu, Yan Xu, Zhe Liu, Hao Ren, Zhengjie Meng, Kuntang Liu, Zhangya Liu, Jiahui Yong, Yonglu Wang^＊,Xueming Li^＊. A modified hydrophobic ion-pairing complex strategy for long-term peptide delivery with high drug encapsulation and reduced burst release from PLGA microspheres. EUR J PHARM BIOPHARM, 2019, 144: 217-229(IF: 5.589/Q1)

10. Yuqian Wang, Zhangya Liu, Hao Wang, Zhengjie Meng, Yonglu Wang, Wenjun Miao,Xueming Li^＊, Hao Ren^＊. Starvation-amplified CO generation for enhanced cancer therapy via erythrocyte membrane-biomimetic gas nanofactory. ACTA BIOMATER, 2019, 92: 241-253(IF: 10.633/Q1)

近期代表性专利：

1. 李学明，王永禄，刘坤堂，陈卫，王栋，李杨，孟政杰，任浩。一种莫沙必利的微孔渗透泵控释片及其制备方法。专利号：ZL 201910322984.8，授权日期：2023.05.05

2. 李学明、刘吉伟、王永禄、任浩、孟政杰、徐妍、陈卫、王栋、李杨。一种抑制PLGA微球中多肽类药物酰化副反应的方法。专利号：ZL 201910387385.4，授权日期：2023.04.07

3. 李学明，任浩，王雨倩，王永禄，孟政杰，陈卫，王栋。一种生物酶催化产气抗肿瘤仿生纳米粒及其制备方法。专利号：ZL201910269453.7，授权日期：2021.09.03

4. 李学明，王永禄，李杨，王栋，陈卫，任浩，刘坤堂，刘吉伟。一种莫沙必利的缓释干混悬剂及其制备方法。专利号：ZL201710692217.7，授权日期：2021.07.02

5. 李学明，陈卫，王永禄，王栋，孙小虎。一种硝苯地平缓释片及其制备方法。专利号：ZL201810120465.9，授权日期：2020.11.03

Email:xuemingli@njtech.edu.cn