赵晔,副教授,硕士生导师,药理学教研室副主任,药学专业负责人。
研究方向:
1.基于疾病动物模型的病理机制研究、药效学及毒理学评价;
2.肝纤维化/早期肝硬化的分子机制探索;
3.绝经后骨质疏松的发病机制及药物筛选;
4.基于微生态探索菌群在疾病发生中的免疫调控机制。
教育及科研经历:
2019/07至今新利18彩票药学院副教授
2016/08-2019/07新利18彩票药学院讲师
2011/11-2014/08新加坡国立大学博士后研究员
2006/09-2011/07北京协和医学院/清华大学医学部 微生物与生化药学 (硕博连读) 博士
2002/09-2006/07沈阳药科大学生物工程 学士
科研项目:
2018/01-2020/12国家自然科学基金青年科学基金项目:Yap与Hedgehog信号在激活HSC诱发肝纤维化中的相互作用机制探索(主持,结题)
2017/01-2020/12江苏省先进生物制造协同创新中心自由探索项目:基于群体感应系统研究新型抗菌肽Gassericin T合成调控机制 (主持,结题)
2019/01-2022/12国家自然科学基金青年项目:MAPK通路调控Prm1在异质细胞融合的作用机制(参与,结题)
获奖情况:
2021年 新利18彩票 国际化工作先进个人
2021年 新利18彩票 本科生毕业设计优秀指导教师
2019年第四届全国大学生生命科学创新创业大赛指导教师一等奖
2018、2021年新利18彩票 药学院年度考核优秀教师
2017年新利18彩票 校级优秀指导教师二等奖
论文及专利:
He T, Lykov N, et. al,Zhao Y*, Tzeng C*. Protective Effects of Lactobacillus gasseri against high-cholesterol diet-induced fatty liver and regulation of host gene expression profiles. Int J Mol Sci, 2023.
Zhang X, Retyunskiy V, Qiao S,Zhao Y*, Tzeng C*. Alloferon-1 ameliorates acute inflammatory responses in λ-carrageenan-induced paw edema in mice. Sci Rep, 2022.
Zhao Y*, Wang T, Chen Z, et.al. Development and evaluation of a thermosensitive in Situ gel formulation for intravaginal delivery of lactobacillus gasseri. Pharmaceutics, 2022.
Zhao Y*, Duah P, Liu Y, et.al, Zinc pyrithione (ZPT)-induced embryonic toxicogenomic responses reveal involvement of oxidative damage, apoptosis, endoplasmic reticulum (ER) stress and autophagy. Aquatic Toxicology, 2022.
Zhao Y*, L Nikita, Tzeng CM, Talin-1 interaction network in cellular mechanotransduction,Int J Mol Med, 2022.
Zhao Y, Lu C, Wang H, et.al, Identification of hsa-miR-1275 as a novel biomarker targeting MECP2 for human epilepsy of unknown etiology, Molecular Therapy-Methods & Clinical Development, 2020.
Zhao Y*, Meng F, Ding C, et.al, Gender-differentiated metabolic abnormalities of adult zebrafish with zinc pyrithione (ZPT) -induced hepatotoxicity, Chemosphere, May, 2020.
Zhao Y*, Wang H, Li T, et.al, Baicalin ameliorates dexamethasone-induced osteoporosis by regulation of the RANK/RANKL/OPG signaling pathway. Drug design, Development and Therapy, Jan, 2020.
Zhao Y, Cai L, Wang H, et.al, 1,25-Dihydroxyvitamin D3 affects gastric cancer progression by repressing BMP3 promoter methylation. OncoTargets and Therapy, 12:2343-2353, Mar, 2019.
Zhao Y*, Liu Y, Sun J, et.al, Acute toxic responses of embryo-larval zebrafish to zinc pyrithione (ZPT) reveal embryological and developmental toxicity, Chemosphere, 205:62-70, Aug, 2018.
Yu Y, Qi Y, et. al,Zhao Y*, Effect of bulk MoS2 on the metabolic profile of yeast, Journal of Nanoscience and Nanotechnology, 2017.
Zhao Y, Huang X, Ding TW, Gong Z, Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish, Scientific Reports, 6:31952 Aug, 2016.
Zhao Y, Qin W, Hu Z, et. al, HCV IRES-mediated core expression in zebrafish. PLoS ONE, Mar, 2013.
专利:
赵晔,杜展翔,刘复昌.一种基于联邦学习和神经网络的抗病毒肽预测方法及系统,中华人民共和国专利, CN115700886, 2023.
赵晔,曾子晏,王天园,孟凡荣.一种含活性加氏乳杆菌的妇科原位温敏凝胶制剂及其制备和应用,中华人民共和国专利, CN202111186146.6, 2021.
曾骥孟,黄宝琪,宋萍,赵晔,胡鹏,陈帅.一种加氏乳杆菌及其在制备早产药物中的应用,中华人民共和国专利, CN109402002A, 2018.
张靖溥,丁存宝,蒋建东,赵晔, HCV斑马鱼亚复制子模型,中华人民共和国专利, CN102578039A, 2012.
E-mail:zhaoye@njtech.edu.cn。