报告题目：恶臭假单胞菌尼古丁分解代谢机制研究
报告人：唐鸿志 副研究员
时间：2014.4.3 下午14:00
地点：生工学科楼A1楼一层报告厅
唐鸿志副研究员简介：
上海交通大学生命科学技术学院/微生物代谢国家重点实验室副研究员，硕士生导师，上海市“青年科技启明星”，上海市“晨光学者”，上海交通大学“晨星学者”，上海交通大学“青年岗位能手”。2013年度获得上海市“明治乳业生命科学奖”和“益海嘉里青年教师奖”。
研究领域：环境有机污染物的微生物分解代谢机制研究。首次系统地阐明了困惑科学家近60年的假单胞菌代谢尼古丁的分子机理，并提出了尼古丁代谢高值中间物的制备，实现变废为宝的观点。已发表SCI论文48篇(第一/通讯作者15篇)，他引400次以上。如以第一作者在遗传学领域主流期刊PLoS. Genet.（Top，1区），微生物学领域顶级期刊Mol. Microbiol.（Top）（2篇）、Appl. Environ. Microbiol.（2篇）、J. Bacteriol.、生物化学领域顶级期刊J. Biol. Chem.（Top）（1篇）等期刊发表。获得授权专利6项。担任Journal of Food Processing & Beverages和American Journal of Experimental Biology杂志编委，并担任Appl. Microbiol. Biotechnol.、J. Appl. Microbiol.、Process Biochem.、Biochem. Eng. J.等杂志审稿人。
代表性论文发表：
1.Tang H. Z., Wang L. J†., Wang W. W†., Yu H†., Zhang K. Z., Yao Y. X., and Xu P*. Systematic unraveling of the unsolved pathway of nicotine degradation inPseudomonas.PLoS. Genet.9(10):e1003923. 2013.
2. Chen D. D†.,Tang H. Z†., Lv Y., Zhang Z.Y., Shen K. L., Lin K., Zhao Y. L., Wu G*., and Xu P*. Structural and computational studies of the maleate isomerase fromPseudomonas putidaS16 reveal a breathing motion wrapping the substrate inside.Mol. Microbiol., 87(6):1237-1244. 2013.
3.Tang H. Z., Yao Y. X†., Zhang D. K†., Meng X. Z†., Wang L. J†., Yu H†., Ma L. Y., and Xu P*. A Novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation byPseudomonas putida.J. Biol. Chem.286(45):39179-39187. 2011.
4.Tang H. Z., Wang L. J., Meng X. Z., Ma L. Y., Wang S. N., He X. F., Wu G., and Xu P*. Novel nicotine oxidoreductase-encoding gene involved in nicotine degradation byPseudomonas putidastrain S16.Appl. Environ. Microbiol.75(3):772-778. 2009.
5. Wu G†., Chen D. D†.,Tang H. Z†., Ren Y. L., Chen Q. H., Lv Y., Zhang Z. Y., Zhao Y. L*., Yao Y. X., and Xu P*. Structural insights into the specific recognition ofN-heterocycle biodenitrogenation-derived substrates by microbial amide hydrolases.Mol. Microbiol., Article first published online: 23 Jan 2014. DOI:10.1111/mmi.12511. 2014.
6. Wang L. J.,Tang H. Z., Yu H., Yao Y. X., and Xu P*. An unusual repressor controls the expression of a crucial nicotine-degrading gene cluster inPseudomonas putidaS16.Mol. Microbiol., Article first published online: 20 Feb 2014. DOI:10.1111/mmi.12533. 2014.
7. Liu Y. H†., Wang L. J†., Huang K. M., Wang W. W., Nie X. L., Jiang Y., Li P. P., Liu S. S., Xu P., andTangH. Z*. Physiological and biochemical characterization of a novel nicotine-degrading bacteriumPseudomonas geniculataN1.PLoS. ONE.9 (1):e84399. 2014.
8.Tang H. Z*., Li J., Hu H. Y., and Xu P. A newly isolatedStenotrophomonassp. strain hydrolyzes acetamiprid, a synthetic insecticide for controlling insects.Process Biochem.47(12):1820-1825. 2012.
9. Yao Y. X†.,Tang H. Z†*., Ren H. X., Yu H., Wang L. J., and Xu P*. 2012. Genome sequence of a nicotine-degrading strain ofArthrobacter.J. Bacteriol.194:5714-5715.
10.Tang H. Z†., Yu H†., Tai C†., Huang K. M., Liu Y. H., Wang L. J., Yao Y. X., Wu G., and Xu P*. Genome sequence of a novel nicotine-degrading strain,Pseudomonas geniculataN1.J. Bacteriol.194(13):3553-3554. 2012.
11.Tang H. Z†., Yao Y. X†., Wang L. J., Yu H., Ren Y. L., Wu G., and Xu P*.Genomic analysis ofPseudomonas putida: genes in a genome island are crucial for nicotine degradation.Sci. Rep.2:377. 2012.
12.Yu H†.,Tang H. Z†., Wang L. J., Yao Y. X., Wu G., and Xu P*.Complete genome sequence of nicotine-degradingPseudomonas putidastrain S16.J. Bacteriol.193(19):5541-5542. 2011.
13.Tang H. Z., Wang S. N., Ma L. Y., Meng X. Z., Deng Z. X., Zhang D. K., Ma C. Q., and Xu P*. A novel gene encoding 6-hydroxy-3-succinoylpyridine hydroxylase in nicotine degradation byPseudomonas putidastrain S16.Appl. Environ. Microbiol.74(5):1567-1574. 2008.
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